期刊
NATURE GENETICS
卷 47, 期 3, 页码 235-+出版社
NATURE RESEARCH
DOI: 10.1038/ng.3215
关键词
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资金
- Wellcome Trust Senior Investigator Award [095598/Z/11/Z]
- Welcome Trust [RG 0937351Z/10/Z]
- European Research Council (ERC) [BB/H005854/1, 260809]
- Biotechnology and Biological Sciences Research Council
- UK Medical Research Council [G0901388]
- Cancer Research UK Postdoctoral Fellowship
- ERC Starting Grant (SYSGRO)
- Czech Science Foundation [P305/12/P040]
- Charles University [UNCE 204013]
- Cancer Research UK
- BBSRC [BBS/E/T/000PR5885, BB/I012451/1, BB/H005854/1, BB/H008802/1, BBS/E/T/000PR6193, BB/K006320/1] Funding Source: UKRI
- MRC [G0901388, MR/L012561/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I012451/1, BB/H008802/1, BBS/E/T/000PR5885, BBS/E/T/000PR6193, BB/H005854/1, BB/K006320/1] Funding Source: researchfish
- Cancer Research UK [15699] Funding Source: researchfish
- Medical Research Council [MR/L012561/1, G0901388] Funding Source: researchfish
- The Francis Crick Institute [10134] Funding Source: researchfish
- Wellcome Trust [095598/Z/11/Z] Funding Source: researchfish
Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (pi = 3 x 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (similar to 340 BCE), and ancestors of these strains reached the Americas at similar to 1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genomewide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis represents a rich resource to examine genotype-phenotype relationships in a tractable model.
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