期刊
NATURE CHEMISTRY
卷 7, 期 10, 页码 810-815出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.2346
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资金
- DuPont
- National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1655581] Funding Source: National Science Foundation
Chemists have long sought sequence-controlled synthetic polymers that mimic nature's biopolymers, but a practical synthetic route that enables absolute control over polymer sequence and structure remains a key challenge. Here, we report an iterative exponential growth plus side-chain functionalization (IEG+) strategy that begins with enantiopure epoxides and facilitates the efficient synthesis of a family of uniform >3 kDa macromolecules of varying sequence and stereoconfiguration that are coupled to produce unimolecular polymers (>6 kDa) with sequences and structures that cannot be obtained using traditional polymerization techniques. Selective side-chain deprotection of three hexadecamers is also demonstrated, which imbues each compound with the ability to dissolve in water. We anticipate that these new macromolecules and the general IEG+ strategy will find broad application as a versatile platform for the scalable synthesis of sequence-controlled polymers.
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