期刊
NATURE CHEMICAL BIOLOGY
卷 11, 期 10, 页码 772-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.1892
关键词
-
资金
- Ente Cassa di Risparmio [2013/7101]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [CTN01_00177_962865]
- European Integrated Structural Biology Infrastructure (INSTRUCT), European Strategy Forum on Research Infrastructures
In eukaryotes, cytosolic monothiol glutaredoxins are proteins implicated in intracellular iron trafficking and sensing via their bound [2Fe-2S] clusters. We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins. Specific protein recognition between the N-terminal domains of the two proteins is the mandatory requisite to promote the [2Fe-2S] cluster transfer from GRX3 to anamorsin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据