期刊
NATURE
卷 520, 期 7548, 页码 474-482出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature14436
关键词
-
资金
- National Institutes of Health (NIH) [R01NS086907]
- Pew Foundation
- NIH [1K99DE024232]
The origin of vertebrates was accompanied by the advent of a novel cell type: the neural crest. Emerging from the central nervous system, these cells migrate to diverse locations and differentiate into numerous derivatives. By coupling morphological and gene regulatory information from vertebrates and other chordates, we describe how addition of the neural-crest-specification program may have enabled cells at the neural plate border to acquire multipotency and migratory ability. Analysis of the topology of the neural crest gene regulatory network can serve as a useful template for understanding vertebrate evolution, including elaboration of neural crest derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据