期刊
NATURE
卷 518, 期 7538, 页码 197-U401出版社
NATURE PORTFOLIO
DOI: 10.1038/nature14177
关键词
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资金
- ESRC [ES/J023299/1, ES/F02679X/1] Funding Source: UKRI
- MRC [G0600717, G0601261, MC_UU_12015/1, MC_UU_12012/1, G1000616, MR/N01104X/1, G0902037, MC_UU_12019/1, MC_UU_12015/2, MR/K002414/1, MC_PC_U127561128, MC_UU_12013/1, MR/K013351/1, MC_UP_A100_1003, MR/L003120/1, G1001799, G9521010, MC_UU_12015/5, MC_U106179472] Funding Source: UKRI
- British Heart Foundation [RG/10/12/28456, RG/08/008/25291, RG/07/008/23674, RG/08/014/24067, FS/14/55/30806] Funding Source: researchfish
- Cancer Research UK [14136] Funding Source: researchfish
- Chief Scientist Office [CZB/4/710, CZB/4/672] Funding Source: researchfish
- Economic and Social Research Council [ES/J023299/1, ES/F02679X/1] Funding Source: researchfish
- Lundbeck Foundation [R190-2014-3904] Funding Source: researchfish
- Medical Research Council [G0600717, MC_UU_12012/5/B, G0600717B, G0100222, MC_UU_12015/5, MC_U106179472, G19/35, MC_UU_12015/1, G0601261, G1000616, MC_UU_12015/2, MC_UU_12012/1, G0902037, MR/K006584/1, G1000143, MC_PC_U127561128, MC_UU_12019/1, G0401527, MR/L003120/1, MC_UU_12013/1, G8802774, MR/K002414/1, MC_UP_A100_1003, MR/N01104X/1, MC_U106179471, G1001799, G9521010, MR/K013351/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10099, NF-SI-0513-10059, NF-SI-0512-10113, NF-SI-0514-10027, NF-SI-0611-10219, NF-SI-0507-10380, NF-SI-0512-10114, NF-SI-0512-10165, NF-SI-0611-10170, NF-SI-0513-10109] Funding Source: researchfish
- NNF Center for Basic Metabolic Research [Pers Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF15OC0016416, NNF13OC0005785, NNF13OC0004839, NNF14OC0009883, NNF12OC1016467, NNF14OC0010513] Funding Source: researchfish
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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