期刊
NATURE
卷 517, 期 7534, 页码 302-310出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature14190
关键词
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资金
- National Institutes of Health [R01 CA129105, CA103866, AI047389, R21 AG042876]
- American Federation for Aging
- Starr Foundation
- Koch Institute Frontier Research Program
- Ellison Medical Foundation
- Charles King's Trust Foundation/Simeon J. Fortin Fellowship
- American Cancer Society- Ellison Foundation Postdoctoral Fellowship [PE-13-356-01-TBE]
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.
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