期刊
NATURE
卷 518, 期 7539, 页码 344-349出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature14233
关键词
-
资金
- NIH [U01ES017155]
- NIGMS [P01GM099117]
- NHGRI [P50HG006193]
- New York Stem Cell Foundation
- NIH Ruth L. Kirschstein NRSA fellowship [5F32DK095537]
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics la ell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors with extensive epigenume and transcriptional data across the differentiation of human embryonic stem cells to the three germ layers. We describe core regulatory dynamics and show the lineage-specific behaviour of selected factors. In addition to the orchestrated remodelling of the chromatin landscape, we find that the binding of several transcription factors is strongly associated with. specific loss of DNA methylation in one germ layer, and in many cases a reciprocal gain in the other layers. Taken together, our work shows context-dependent rewiring of transcription factor binding, downstream signalling effectors, and the epigenome during human embryonic stem cell differentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据