期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 6, 页码 3683-3686出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.04781-14
关键词
-
资金
- VIDI grant from Netherlands Organization for Scientific Research (NWO)
Nisin and related lantibiotics kill bacteria by pore formation or by sequestering lipid II. Some lantibiotics sequester lipid II into clusters, which were suggested to kill cells through delocalized peptidoglycan synthesis. Here, we show that cluster formation is always concomitant with (i) membrane pore formation and (ii) membrane depolarization. Nisin variants that cluster lipid II kill L-form bacteria with similar efficiency, suggesting that delocalization of peptidoglycan synthesis is not the primary killing mechanism of these lantibiotics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据