期刊
NATURE
卷 526, 期 7575, 页码 653-659出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature15389
关键词
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资金
- Defense Advanced Research Projects Agency Neuro-FAST program
- National Institute of Mental Health, National Science Foundation
- National Institute on Drug Abuse, National Science Foundation
- Simons Foundation
- Tarlton Foundation
- Wiegers Family Fund
- Nancy and James Grosfeld Foundation
- H.L. Snyder Medical Foundation
- Samuel and Betsy Reeves Fund
- Ellison Life Sciences Research Foundation (LSRF) fellowship
- Simons LSRF fellowship
- German Academic Exchange Service DAAD
- Fidelity Foundation
Top-down prefrontal cortex inputs to the hippocampus have been hypothesized to be important in memory consolidation, retrieval, and the pathophysiology of major psychiatric diseases; however, no such direct projections have been identified and functionally described. Here we report the discovery of a monosynaptic prefrontal cortex (predominantly anterior cingulate) to hippocampus (CA3 to CA1 region) projection in mice, and find that optogenetic manipulation of this projection (here termed AC-CA) is capable of eliciting contextual memory retrieval. To explore the network mechanisms of this process, we developed and applied tools to observe cellular-resolution neural activity in the hippocampus while stimulating AC-CA projections during memory retrieval in mice behaving in virtual-reality environments. Using this approach, we found that learning drives the emergence of a sparse class of neurons in CA2/CA3 that are highly correlated with the local network and that lead synchronous population activity events; these neurons are then preferentially recruited by the AC-CA projection during memory retrieval. These findings reveal a sparsely implemented memory retrieval mechanism in the hippocampus that operates via direct top-down prefrontal input, with implications for the patterning and storage of salient memory representations.
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