期刊
JOURNAL OF APPLIED ICHTHYOLOGY
卷 26, 期 2, 页码 225-229出版社
WILEY
DOI: 10.1111/j.1439-0426.2010.01410.x
关键词
-
资金
- FWO-Vlaanderen [3G0040.08]
- Norwegian Research Council [172483/s40]
- COST Action B23
P>The canonical view of a mammalian (usually shown as human) bone resorbing cell is that of a giant macrophage-like cell (osteoclast) that dissolves bone minerals and digests bone matrix proteins. The cells' presence and activity is easily recognised based on three distinct morphological features: (i) multinuclearity, (ii) a multiply folded apical cell membrane (ruffled border), and (iii) deep lacunae (Howship's lacunae) that the cells eroded into the bone surface. Mononucleated osteoclasts without these features are considered to be inactive precursors. We challenge the view that bone resorbing cells must be multinucleated giant cells, based on our comparative studies on the teleost skeleton, on what is currently known - but often disregarded - about mononucleated mammalian osteoclasts, and on what is know about osteocytic osteolysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据