4.3 Article

Transcriptomic portraits of canine mammary cancer cell lines with various phenotypes

期刊

JOURNAL OF APPLIED GENETICS
卷 51, 期 2, 页码 169-183

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/BF03195725

关键词

canine mammary cancer cells; DNA microarray; transcriptomics

资金

  1. Polish Ministry of Science and Higher Education [N308230536]
  2. European Social Fund
  3. Masovia Region
  4. Lower Silesia Region

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In light of the high incidence of mammary cancer in dogs and completion of the canine genome sequencing, the new possibilities of gene profiling by using DNA microarrays give hope to veterinary oncology. The cell lines isolated from mammary tumors are a valuable tool in developing and testing new pathway-specific cancer therapeutics. Differential cytometric analysis of 6 canine mammary cancer cell lines was performed. We divided cell lines into 3 groups based on their phenotype: 2 lines with high proliferative potential, 2 lines with high antiapoptotic potential, and 2 lines with high metastatic potential. DNA microarray analysis revealed common genes for cell lines of each group. We found that genes encoding the receptors for growth hormone and ghrelin are related to high proliferation rate, while A BR (active BCR-related) and TMD1 (TM2 domain containing 1) genes are related to a high antiapoptotic potential of the cancer cells. Metastatic properties of mammary cancer cells seem to be associated with elevated expression of PGP (P glycoprotein), SEMA3B (semaphorin 3B), and (stromal interaction molecule 1).

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