期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 1, 页码 79-84出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1038262
关键词
furan derivative; 5-acetoxymethylfuran-3-carboxylic acid; Aspergillus flavus; Cephalotaxus fortunei
资金
- Specialised Research Fund for the Doctoral Program of Higher Education of China [20116125110001]
- Natural Science Basic Research Plan in Shaanxi Province of China [2014JZ003]
A new furan derivative named 5-acetoxymethylfuran-3-carboxylic acid (2), together with a known furan compound, 5-hydroxymethylfuran-3-carboxylic acid (1), were isolated from the fermentation of Aspergillus flavus, endophytic fungi in Cephalotaxus fortunei. The structures of 1 and 2 were elucidated by NMR, IR, UV and MS data, as well as compared with literature data. The compounds 1 and 2 exhibited potent antibacterial activity against Staphylococcus aureus with MIC values of 31.3 and 15.6 g/mL, respectively. The compound 2 showed moderate antioxidant activity.
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