A new myrsinol-type diterpene polyester from Euphorbia dracunculoides Lam

A new myrsinol-type diterpene polyester, 14-deoxo-3 beta-O-propinoyl-2 alpha,5 alpha,7 beta,15 beta-tetra-O-acetyl-14 alpha-O-benzoyl-myrsinol (1), and its known analogue, 14-deoxo-3 beta-O-prorionyl-5 alpha,15 beta-di-O-acetyl-7 beta-O-nicotinoyl-myrsinol-14 beta-acetate (2), together with a monoterpenoid, pubinernoid A (3), two indole alkaloids, neoechinulin A (4) and dihydroxyisoechinulin A (5), two benzene derivatives, siringin (6) and (3-methoxyphenyl) acetic acid (7), were isolated from the 70% acetone extract of the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated on the basis of spectroscopic evidence and comparison with literature reports. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra. Among them, compounds 4 and 5 were first obtained from the plant source. In addition, the C-13 NMR data of compound 2 was reported for the first time.