期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 2, 页码 138-143出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1045509
关键词
diketopiperazine; cyclodipeptide; Streptomyces sp
资金
- MOST [2012AA092104]
- National Natural Science Foundation of China for Young Scientists [41106138]
- international S&T cooperation program of China [2011DFA32540]
- Knowledge Innovation Programs of CAS [KZCX2-YW-JC202, KSCX2-EW-G-12]
A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2-6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1-6 did not show cytotoxic activity at a concentration of 100M in bioactivity assay.
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