期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 67, 期 5, 页码 1167-1169出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dks009
关键词
carbapenems; aztreonam; oxacillinase; tigecycline
资金
- Basilea Pharmaceutica International Ltd.
- Bundesministerium fur Bildung und Forschung (BMBF), Germany, Klinische Forschergruppe Infektiologie [01KI0771]
- Novartis
- Pfizer
The activity of BAL30072 was compared with that of anti-Acinetobacter reference drugs against meropenem-non-susceptible Acinetobacter baumannii isolates associated with up-regulation of the intrinsic OXA-51-like enzyme or an acquired OXA. Antimicrobial susceptibility testing was investigated by broth microdilution of 310 non-duplicate, meropenem-non-susceptible A. baumannii isolates to BAL30072, amikacin ampicillin/sulbactam, aztreonam, cefepime, colistin, imipenem, levofloxacin, meropenem, rifampicin, tigecycline and tobramycin. BAL30072 showed greater activity than the -lactam comparators, levofloxacin, amikacin, tobramycin and rifampicin. The activity of BAL30072 was comparable to that of tigecycline, with an MIC50 of 2 mg/L. Elevated BAL30072 MICs were found, but there was no correlation with elevated MICs of the other antimicrobials. BAL30072 is a promising new agent with good activity against carbapenem-non-susceptible A. baumannii.
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