期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 11, 页码 1335-1338出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1055743
关键词
Nelumbo nucifera; antioxidant; cholinesterase inhibition; essential oil; GC-MS analysis
Nelumbo nucifera seeds' essential oil (EO), crude extract and subsequent fractions were evaluated for their DPPH, ABTS and superoxide anion-free radical scavenging and cholinesterase inhibitory activities. The ethyl acetate fraction and EO showed outstanding antioxidant activities with IC50 values of 191, 450g/mL (DPPH), 123, 221g/mL (ABTS) and 69, 370g/mL (superoxide anion). The ethyl acetate fraction and EO also caused significant inhibition of acetylcholinesterase and butyrylcholinesterase with IC50 values of 70 +/- 0.6, 64 +/- 0.8 and 75 +/- 0.3, 58 +/- 0.2, in dose-dependent manner. The first ever gas chromatography-mass spectrometry analysis of the EO obtained from N. nucifera seeds resulted in identification of 19 constituents, mainly comprised of oxygenated sesquiterpenes responsible for their promising bioactivity. The crude and fractions revealed the presence of saponins, flavonoids, steroids, alkaloids, terpenoids and cardiac glycosides in phytochemical investigation.
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