期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 2, 页码 144-149出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1045904
关键词
ent-atisane; Euphorbia fischeriana Steud; X-ray; stereoismers; anti-tumour activity
资金
- National Basic Research Program of China [973 Program] [2013CB531801]
- Foundation of Research and Innovation for Graduate Student of Heilongjiang Province [YJSCX2012-354HLJ]
Two new ent-atisanes ent-1,3,16,17-tetrahydroxyatisane (1), ent-1,3,16,17-tetrahydroxyatisane (2) together with 11 known diterpenes were isolated from the anti-tumour activity fraction of Euphorbia fischeriana Steud. The compounds were identified by detailed spectroscopic analysis, including extensive 2D-NMR experiments. X-ray analysis was applied to determine the structure of compound 2. All 13 compounds were screened for cytotoxicity in vitro against human tumour MCF-7, HepG-2 and SGC-7901 cell lines. Compounds 1 and 2 showed the inhibitory effects against MCF-7 with IC50 levels of 23.21 and 15.42M; simultaneously, compounds 4, 6, 8 and 11 also had definite inhibitory effect against different cell lines.
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