期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 66, 期 9, 页码 2070-2074出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkr239
关键词
polymyxins; carbapenems; antimicrobial activity; drug resistance
资金
- JMI Laboratories, North Liberty, IA, USA
Objectives: To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40625 Gram-negative bacilli. Methods: Antimicrobial susceptibility testing was performed and interpreted using the CLSI broth microdilution method except for colistin against Enterobacteriaceae. Results: The polymyxins showed potent in vitro activities (MIC(90), <= 0.5-1 mg/L) against this large collection of clinical isolates, with very low resistance rates (<0.1%-1.5%). Resistance to the polymyxins remained stable among organisms tested except for Klebsiella spp. isolates collected from the Asia-Pacific and Latin American regions, where a trend towards greater resistance was observed (P <= 0.05). In addition, an important reduction in imipenem susceptibility among Acinetobacter spp. and Klebsiella spp. was demonstrated in most geographical regions. Conclusions: Although the polymyxins showed excellent in vitro activity against the vast majority of Gram-negative bacilli evaluated, a trend to greater resistance was observed in the Asia-Pacific and Latin American regions. Therefore, the clinical use of polymyxins must be cautious and surveillance monitored.
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