期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 22, 页码 2590-2593出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1114941
关键词
Aconitum spicatum; antileishmanial activity; Leishmania major; diterpenoid alkaloids
资金
- World Academy of Sciences for Developing World (TWAS) [11-010-RG/CHE/AS_G UNESCO FR: 3240262700]
The crude extracts of tubers of Aconitum spicatum (Bruhl) Stapf were investigated for in vitro antileishmanial activity against Leishmania major. The dichloromethane extract at pH 2.5 showed antileishmanial activity with IC50 value of 27.10 +/- 0.0g/mL. Chromatographic purification of the dichloromethane extract led to isolation of three C-19 norditerpenoid alkaloids indaconitine (1), chasmaconitine (2) and ludaconitine (3). Compounds 3 and 2 showed antileishmanial activity with IC50=36.10 +/- 3.4 and 56.30 +/- 2.1g/mL, respectively. Compound 1 was less effective (IC50>100g/mL). The cytotoxicity of compounds 1, 2 and 3 studied against MCF7, HeLa and PC3 cancer cell lines and 3T3 normal fibroblast cell line did not show cytotoxicity at 30M.
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