期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 66, 期 7, 页码 1590-1593出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkr182
关键词
debridement and retention; biomarker; two-stage revision; sensitivity; specificity
资金
- NIHR Biomedical Research Centre in Oxford
- Corin Group
Objectives: Prosthetic joint infection is usually treated using surgery and antibiotics. The response to the treatment regimen is often evaluated using serial monitoring of plasma C-reactive protein (CRP) concentrations. In order to examine how useful this monitoring is, we calculated the sensitivity and specificity of CRP concentrations for predicting treatment failure. Patients and methods: We examined 3732 CRP measurements from 260 patients who were treated by either two-stage revision or debridement and retention. We tested the association between CRP concentration and outcome using logistic regression models, and assessed sensitivity and specificity by using receiver operator curves. Results: The areas under receiver operator curves for CRP concentrations predicting outcome ranged from 0.55 to 0.65. Conclusions: CRP concentrations did not accurately predict treatment failure. Serial monitoring may not be of benefit.
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