期刊
NATURAL PRODUCT RESEARCH
卷 29, 期 11, 页码 1078-1082出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.981181
关键词
luteolin; d-galactose; oxidative stress; inflammation; kidney
资金
- 'Qing-Lan' Project of Jiangsu Province
- 'Liu Da Ren Cai Gao Feng' Project of Jiangsu Province [2011-YY-13]
- Industrialization of Scientific Research Promotion Projects of Universities and Colleges in Jiangsu Province [2011-16]
- Natural Science Fund for Universities and Colleges in Jiangsu Province [11KJB350005]
- foundation of School of Pharmacy in Xuzhou Medical College [2011YKJ004]
- Foundation of Xuzhou Medical College Key Laboratory of Tumor Biology Therapy [C0904, JSBL0803, C0903]
- Science and Technology Plan Projects of Xuzhou [XF11C037, XF11C062, XZZD1227, XZZD1219]
- Superiority Academic Discipline Construction Project of Jiangsu Higher Education Institutions
- Post-doctoral Fund in Jiangsu Province [1201036B]
- research project of Xuzhou [BRA201205]
Luteolin is reported to have antioxidant and anti-inflammatory properties. In this study, we investigated the protective effect of luteolin against the renal damage induced by d-galactose (d-gal). The levels of creatinine (Cr) and urea nitrogen (BUN) were evaluated in plasma, kidney sections were stained with haematoxylin-eosin, followed by assessment of the antioxidant and anti-inflammatory activity. Furthermore, we also investigated the expression of the p38 mitogen-activated protein kinase (p38 MAPK) and its phosphorylated activation. The results of luteolin treatment showed that the renal damages were attenuated. Luteolin could significantly ameliorate d-gal-induced oxidative damage and suppress the inflammatory response. Moreover, the result also shows that luteolin could significantly inhibit the p38 MAPK phosphorylation in the kidneys from the model of d-gal-treated mice. Therefore, our research suggests that luteolin might be involved in the attenuated oxidative stress and inflammatory responses, hence the protective effects against d-gal-induced renal damage.
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