期刊
JOURNAL OF ANTIBIOTICS
卷 72, 期 1, 页码 45-49出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0103-6
关键词
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资金
- National Natural Science Foundation of China [41776169, 41476135, 21502204, 21772210, 81741154, 81741158]
- Science and Technology Project of Guangdong Province [2016A020222010]
- Pearl River S&T Nova Program of Guangzhou [201710010136]
- High Education Teaching and reform Research Fund Program of Hainan province [Hnjg2017ZD-3]
Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively.
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