期刊
JOURNAL OF ANTIBIOTICS
卷 68, 期 2, 页码 121-125出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2014.97
关键词
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资金
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- 863 Program [2012AA092104, 2013AA092902]
- National Natural Science Foundation of China [52102308, 21172230, 20902094, 41176148, 21002110, 31270402, 21172094, 41376155]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
A new (2) and four known (1, 8-10) sesquiterpenoids, two new (3 and 4) and eight known (5-7, 11-15) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1-15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5, 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3, 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4, 5 and 11 showed activities against intestinal virus EV71.
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