期刊
JOURNAL OF ANTIBIOTICS
卷 67, 期 6, 页码 445-450出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2014.14
关键词
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资金
- Takeda Science Foundation
- JSPS KAKENHI [25870704]
- Grants-in-Aid for Scientific Research [25870704] Funding Source: KAKEN
Citridone A (1), originally isolated as a potentiator of antifungal miconazole activity from a fungal culture broth, has a phenyl-R-furopyridone structure. Because of its unique ring structure, 11 derivatives were chemically synthesized and their biological activity was evaluated. Derivatives 17, 20 and 21 potentiated miconazole activity against Candida albicans. Furthermore, 1, 14, 20 and 21 were found to inhibit yellow pigment production in methicillin-resistant Staphylococcus aureus.
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