期刊
JOURNAL OF ANTIBIOTICS
卷 67, 期 1, 页码 53-58出版社
SPRINGERNATURE
DOI: 10.1038/ja.2013.77
关键词
agriculture; antibiotics; bacteria; fungus farming; insects; multilateral symbiosis; natural products
资金
- National Institutes of Health (NIH) [R01 GM086258, GM096347]
- National Science Foundation (NSF) [MCB-0702025]
- German National Academy of Sciences Leopoldina
- NATIONAL CANCER INSTITUTE [R01CA059021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM086258, RC4GM096347] Funding Source: NIH RePORTER
As increased antibiotic resistance erodes the efficacy of currently used drugs, the need for new candidates with therapeutic potential grows. Although the majority of antibiotics in clinical use originated from natural products, mostly from environmental actinomycetes, high rediscovery rates, among other factors, have diminished the enthusiasm for continued exploration of this historically important source. Several well-studied insect agricultural systems have bacterial symbionts that have evolved to produce small molecules that suppress environmental pathogens. These molecules represent an underexplored reservoir of potentially useful antibiotics. This report describes the multilateral symbioses common to insect agricultural systems, the general strategy used for antibiotic discovery and pertinent examples from three farming systems: fungus-farming ants, southern pine beetles (SPBs) and fungus-growing termites.
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