期刊
JOURNAL OF ANTIBIOTICS
卷 66, 期 3, 页码 141-145出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2012.125
关键词
cyclopropanation; garsubellin A; natural product; stereoselective synthesis; total synthesis
资金
- [2105]
- Grants-in-Aid for Scientific Research [21106001, 21106009] Funding Source: KAKEN
The stereoselective total synthesis of garsubellin A is described. The total synthesis was achieved through the stereoselective construction of a bicyclo[3.3.1] nonane derivative via a three-step sequence: intramolecular cyclopropanation, formation of a germinal dimethyl group, and regioselective ring opening of cyclopropane. To complete the total synthesis of garsubellin A, chemo-and stereoselective hydrogenation to generate the C8 stereogenic center is followed by the formation of the fused tetrahydrofuran ring by a regioselective epoxide-opening reaction with C3 ketone, and finally cross metathesis to construct two prenyl groups. The Journal of Antibiotics (2013) 66, 141-145; doi: 10.1038/ja.2012.125; published online 6 February 2013
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