期刊
JOURNAL OF ANTIBIOTICS
卷 65, 期 8, 页码 413-417出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2012.40
关键词
azaphilones; Chaetomium sp; chaetomugilins; cytotoxicity; dechlorine derivative
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [23590028] Funding Source: KAKEN
Three new metabolites, chaetomugilin S, dechloro-chaetomugilin A and dechloro-chaetomugilin D, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and some chemical transformations. Particularly, chaetomugilins T and U are the first compouds without a chlorine atom in azaphilones isolated from this fungal strain, to date. In addition, these compounds moderately inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines. The Journal of Antibiotics (2012) 65, 413-417; doi:10.1038/ja.2012.40; published online 23 May 2012
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