期刊
NATURAL PRODUCT REPORTS
卷 32, 期 5, 页码 738-751出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4np00167b
关键词
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资金
- National Institutes of Health (NIH) [R01GM085770]
- NIH [U01 TW0007401, R37 CA044848, R01CA127622]
- FOGARTY INTERNATIONAL CENTER [U19TW007401, U01TW007401] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R37CA044848, R01CA127622] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085770] Funding Source: NIH RePORTER
This review covers the initial discovery of the marine actinomycete genus Salinispora through its development as a model for natural product research. A focus is placed on the novel chemical structures reported with reference to their biological activities and the synthetic and biosynthetic studies they have inspired. The time line of discoveries progresses from more traditional bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target the products of specific biosynthetic gene clusters. This overview exemplifies the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.
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