A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp SANK 60405

During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The structural elucidations were carried out by NMR and high-resolution mass spectral analyses, and they were classified as members of the liponucleoside antibiotics group with a sulfate group at the C-2' position. A-90289 A and B inhibited bacterial translocase I with IC50 values of 36.5 ng ml(-1) and 33.8 ng ml(-1), respectively. The Journal of Antibiotics (2011) 64, 495-501; doi: 10.1038/ja.2011.38; published online 18 May 2011