期刊
JOURNAL OF ANTIBIOTICS
卷 64, 期 1, 页码 27-34出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2010.136
关键词
antimicrobial peptide; lantibiotics; mutagenesis; structure activity; structural variant
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Research Chair in Bioorganic and Medicinal Chemistry
There has been great interest in the development of extremely potent antibacterial lantibiotic peptides for medicinal use and in food preservation. Of central importance to this endeavor is a strong understanding of which parts of the peptides are required for activity and which parts are expendable. Nisin, lacticin 481, nukacin ISK-1, mersacidin, lacticin 3147 and haloduracin represent many different types of lantibiotic peptides. In recent years, considerable advances toward understanding the structure-activity relationship of each of these lantibiotic systems have been achieved. This review will focus on the individual systems and the valuable information obtained from the many mutants produced. The Journal of Antibiotics (2011) 64, 27-34; doi:10.1038/ja.2010.136; published online 17 November 2010
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