期刊
JOURNAL OF ANTIBIOTICS
卷 63, 期 9, 页码 545-548出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2010.94
关键词
angucycline; antimicrobial activity; butenolide; cytotoxicity; dichlorocyclopropane; lichen; Streptomyces
资金
- New Energy and Industrial Technology Development Organization (NEDO), Japan
A new 1,1-dichlorocyclopropane-containing angucycline, JBIR-88 (1), and a new butenolide, JBIR-89 (2), respectively, were isolated from the fermentation broths of two lichen-derived actinomycetes identified as a new species of Streptomyces (strains RI104-LiC106 and RI104-LiB101) using phylogenetic methods. The structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compound 1 showed cytotoxic activities against cancer cells and antimicrobial activity against Micrococcus luteus. The Journal of Antibiotics (2010) 63, 545-548; doi:10.1038/ja.2010.94; published online 28 July 2010
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