期刊
JOURNAL OF ANTIBIOTICS
卷 62, 期 4, 页码 177-180出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2009.13
关键词
antioxidative agent; JBIR-12; Penicillium sp.; radical scavenging
资金
- New Energy and Industrial Technology Department Organization (NEDO) of Japan
In the course of our screening program for active compounds from fungal metabolites, we isolated JBIR-12 (1) as a free radical scavenger from the culture broth of Penicillium sp. NBRC 103941. Structure elucidation of 1 was carried out using methylated and/or acetylated derivatives of 1. As a consequence, the structure of 1 was determined to be a novel highly oxygenated tetrahydronaphthalene species attached to an acyl chain moiety on the basis of NMR and other spectroscopic data. It was interesting that 1 was spontaneously methylated when left in methanol. Furthermore, isomerization or rearrangements could occur during the derivatization of 1. Compound 1 exhibited potent radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical with an IC50 value of 75 mu m. The Journal of Antibiotics (2009) 62, 177-180; doi:10.1038/ja.2009.13; published online 27 February 2009
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