期刊
JOURNAL OF ANTIBIOTICS
卷 61, 期 11, 页码 687-691出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2008.98
关键词
macrolactin; Bacillus; FabG; antibacterial; Staphylococcus aureus
资金
- Ministry of Science & Technology, Republic of Korea [MG08-0304-2-0]
In the course of screening for FabG inhibitors from microbial Sources, a new 24-membered ring lactone named macrolactin S. along with the known compound macrolactin B, has been isolated from the mycelium of liquid fermentation Cultures of Bacillus sp. AT28. The structure of macrolactin S was determined on the basis of MS and NMR data. Macrolactin S showed a dose-dependent inhibition of Staphylococcus aureus FabG, not inhibiting S. aureus Fabl. Also macrolactin S inhibited the growth of S. aureus, Bacillus subtilis, and Escherichia coli.
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