期刊
JOURNAL OF ANTIBIOTICS
卷 61, 期 12, 页码 752-755出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2008.89
关键词
Streptomyces versipellis; versipelostatin; molecular chaperone; GRP78
资金
- New Energy and Industrial Technology Development Organization of Japan (NEDO)
- Ministry of Education, Culture, Sports, Science and Technology, Japan
A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC50 value of 0.3 mu M, which is 10-times more potent compared with that of 1.
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