4.5 Article

New sulfoalkylresorcinol from marine-derived fungus, Zygosporium sp KNC52

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JOURNAL OF ANTIBIOTICS
卷 61, 期 3, 页码 192-194

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JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2008.29

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marine-derived fungus; sulfoalkylresorcinol; FtsZ

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A new sulfoalkylresorcinol (1) was isolated from the marine-derived Fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polymerization in vitro and exhibited weak antimicrobial activity against multi-drugresistant bacteria.

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