期刊
NANOTOXICOLOGY
卷 10, 期 1, 页码 32-41出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2014.1002868
关键词
Adverse outcome pathway; gene; mass spectrometry; nanomaterial; nanotoxicology
资金
- UK Natural Environment Research Council [NE/H008764/1, NE/H013148/1]
- Center for Environmental Nanoscience and Risk
- Advantage West Midlands (AWM)
- NERC [NE/H013148/1, NE/H008764/1] Funding Source: UKRI
- Natural Environment Research Council [NE/H008764/1, NE/H013148/1] Funding Source: researchfish
Ceria nanoparticles (NPs) are widely used as fuel catalysts and consequently are likely to enter the environment. Their potential impacts on. biota at environmentally relevant concentrations, including uptake and toxicity, remain to be elucidated and quantitative data on which to assess risk are sparse. Therefore, a definitive assessment of the molecular and phenotypic effects of ceria NPs was undertaken, using well-characterised mono-dispersed NPs as their toxicity is likely to be higher, enabling a conservative hazard assessment. Unbiased transcriptomics and metabolomics approaches were used to investigate the potential toxicity of tightly constrained 4-5nm ceria NPs to the unicellular green alga, Chlamydomonas reinhardtii, a sentinel freshwater species. A wide range of exposure concentrations were investigated from predicted environmental levels, to support hazard assessment, to supra-environmental levels to provide insight into molecular toxicity pathways. Ceria NPs were internalised into intracellular vesicles within C. reinhardtii, yet caused no significant effect on algal growth at any exposure concentration. Molecular perturbations were only detected at supra-environmental ceria NP-concentrations, primarily down-regulation of photosynthesis and carbon fixation with associated effects on energy metabolism. For acute exposures to small mono-dispersed particles, it can be concluded there should be little concern regarding their dispersal into the environment for this trophic level.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据