期刊
JOURNAL OF ANESTHESIA
卷 27, 期 6, 页码 951-955出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00540-013-1629-1
关键词
Argatroban; CPB; Heparin-induced thrombocytopenia type II
Argatroban was used as the anticoagulant during cardiopulmonary bypass (CPB) in a patient with heparin-induced thrombocytopenia (HIT) type II undergoing mitral valve replacement. Dosage was reduced because of preoperative congestive liver disorder. Perioperative coagulability was poor, and, ultimately, failure of hemostasis led to a fatal outcome. Although argatroban use as an anticoagulant for HIT is reported, the optimal dose has not been established. During long-term CPB, increasing the total dosage may extend anticoagulant ability, leading to dose dependence. Because no antagonist for argatroban
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