期刊
JOURNAL OF ANESTHESIA
卷 25, 期 6, 页码 942-945出版社
SPRINGER TOKYO
DOI: 10.1007/s00540-011-1216-2
关键词
Neurosteroid; Neuropathic pain; Hyperalgesia
资金
- Ministry of Education, Science, Sports and Culture of Japan [22791436]
- Grants-in-Aid for Scientific Research [21592008, 22791436] Funding Source: KAKEN
The neurosteroid allopregnanolone (AP) influences the excitability of the central nervous system by acting as a positive allosteric modulator of gamma-aminobutyric acid type A (GABA(A)) receptors. Here, we investigated the role of AP and its therapeutic potential in rats that showed hyperalgesic behavior after undergoing spinal nerve ligation (SNL). AP levels measured in the spinal cord and brain of rats that underwent SNL were greater than the corresponding levels in control animals. More importantly, spinal AP levels in hyperalgesic rats were lower than those in the rats that did not develop hyperalgesia following SNL; in contrast, brain AP levels were comparable among these groups. No differences in serum AP levels were observed among the groups. In addition, intrathecal exogenous administration of AP showed the antihyperalgesic effects in hyperalgesic rats after SNL. These findings suggest that changes in spinal AP biosynthesis are involved in the pathogenesis of neuropathic pain following peripheral nerve injury, and pharmacological manipulation of this phenomenon may provide a potential therapeutic target for neuropathic pain.
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