期刊
JOURNAL OF ANDROLOGY
卷 29, 期 5, 页码 488-498出版社
AMER SOC ANDROLOGY, INC
DOI: 10.2164/jandrol.108.005132
关键词
oxidative stress; testis; male infertility; apoptosis
类别
资金
- NIH [R01-53072, P50-DK45179]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P50DK045179] Funding Source: NIH RePORTER
Oxidative stress results from the production of oxygen radicals in excess of the antioxidant capacity of the stressed tissue. Many conditions or events associated with male infertility are inducers of oxidative stress. X-irradiation, for example, or exposure to environmental toxicants and the physical conditions of varicocele and cryptorchicism have been demonstrated to increase testicular oxidative stress, which leads to an increase in germ cell apoptosis and subsequent hypospermatogenesis. Such stress conditions can cause changes in the dynamics of testicular microvascular blood flow, endocrine signaling, and germ cell apoptosis. Testicular oxidative stress appears to be a common feature in much of what underlies male infertility, which suggests that there may be benefits to developing better antioxidant therapies for relevant cases of hypospermatogenesis.
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