期刊
JOURNAL OF ANALYTICAL CHEMISTRY
卷 69, 期 14, 页码 1337-1343出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1061934814140068
关键词
atenolol; bisoprolol; enalapril; metoprolol; nifedipine; propranolol; GC-MS; artifacts; acute overdose
A method is developed for the detection of some antihypertensive drugs, atenolol, bisoprolol, enalapril, metoprolol, nifedipine and propranolol by gas chromatography coupled with mass spectrometry. It is also applicable to screening in clinical toxicology and the identification of both intact APDs and their metabolites. The chances that propranolol, bisoprolol, atenolol, enalapril, and nifedipine form some artifacts in the analysis are assessed. The structures of these compounds are elucidated and a mechanism of their formation in the chromatograph injector is proposed.
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