Direct analysis of alkylphenols in Ginkgo biloba leaves by thermochemolysis-gas chromatography/mass spectrometry in the presence of tetramethylammonium hydroxide

Thermochemolysis-gas chromatography/mass spectrometry (GC/MS) in the presence of tetramethylammonium hydroxide (TMAH) was applied to the determination of alkylphenols in Ginkgo biloba leaves directly using a vertical microfurnace pyrolyzer. TMAH thermochemolysis-GC enabled the highly sensitive determination of alkylphenols including ginkgolic acids and ginkgols in G. biloba leaves as their methyl derivatives on the resulted pyrograms. On the basis of their peak areas, the contents of the alkylphenols in G. biloba leaf sample were rapidly and precisely determined without using any tedious and time-consuming pretreatment. (C) 2008 Elsevier B.V. All rights reserved.