期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 66, 期 1, 页码 271-280出版社
IOS PRESS
DOI: 10.3233/JAD-180087
关键词
Alzheimer's disease; atypical AD; cerebrospinal fluid examination; parietal lobe; semantic variant of primary progressive aphasia; single photon emission computed tomography
资金
- 'France Alzheimer' Foundation
- 'Philippe Chatrier' Foundation
Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer's disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.
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