期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 39, 期 3, 页码 565-574出版社
IOS PRESS
DOI: 10.3233/JAD-131058
关键词
Aging; Alzheimer's disease; cognition; cohort studies; genetics; polygenic traits
资金
- UK's Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC
- Royal Society
- Chief Scientist Office of the Scottish Government
- Research Into Ageing
- Wellcome Trust
- Alzheimer's Research Trust
- Social Science Research Council
- Medical Research Council
- Economic and Social Research Council
- Unilever plc.
- Medical Research Council (MRC)
- Alzheimer's Research Trust (ART)
- Welsh Assembly Government
- Alzheimer's Society
- Ulster Garden Villages
- N. Ireland RD Office
- Royal College of Physicians/Dunhill Medical Trust
- Bristol Research into Alzheimer's and Care of the Elderly
- NIH
- Barnes Jewish Foundation
- Charles and Joanne Knight Alzheimer's Research Initiative
- Lundbeck SA
- German Federal Ministry of Education and Research (BMBF), Competence Network Dementia and Competence Network Degenerative Dementia
- Alfried Krupp von Bohlen und Halbach-Stiftung
- Helmholtz Zentrum Munchen
- German Research Center for Environmental Health
- BMBF
- German National Genome Research Network
- Munich Center of Health Sciences
- Heinz Nixdorf Foundation
- NINDS
- National Institute on Aging
- MRC
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Allergy and Infectious Diseases
- National Human Genome Research Institute
- National Institute of Child Health and Human Development
- Juvenile Diabetes Research Foundation International
- EPSRC
- ESRC
- Mercer's Institute for Research on Ageing
- Charles Wolfson Charitable Trust
- BBSRC [BB/F019394/1, BB/F022441/1] Funding Source: UKRI
- MRC [G0100266, G0700704, G1001375] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F022441/1, BB/F019394/1] Funding Source: researchfish
- Medical Research Council [G0100266, G0700704, G1001375, MR/K026992/1] Funding Source: researchfish
- Chief Scientist Office [ETM/55, CZB/4/505] Funding Source: researchfish
Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.
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