期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 35, 期 3, 页码 427-440出版社
IOS PRESS
DOI: 10.3233/JAD-122011
关键词
Alzheimer's disease; carbon dioxide; cognitive impairment; vascular; vasoreactivity
资金
- [HL111724-01]
- [NIH-NIA AG12101]
- [AG13616]
- [AG022374]
There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据