期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 26, 期 -, 页码 123-133出版社
IOS PRESS
DOI: 10.3233/JAD-2011-0010
关键词
Alzheimer's disease; hypoperfusion; perfusion; stroke; mild cognitive impairment; ASL; MRI; vascular risk factors
资金
- NCRR NIH HHS [UL1 RR025011-04, UL1 RR025011-05, UL1 RR025011] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007936, T32 HL007936-11, T32 HL007936-12, T32 HL007936-10] Funding Source: Medline
- NICHD NIH HHS [P30 HD003352] Funding Source: Medline
- NIMH NIH HHS [RC1 MH090912, RC1 MH090912-01, RC1 MH090912-02] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD003352] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025011] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007936] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [RC1MH090912] Funding Source: NIH RePORTER
The role of hypoperfusion in Alzheimer's disease (AD) is a vital component to understanding the pathogenesis of this disease. Disrupted perfusion is not only evident throughout disease manifestation, it is also demonstrated during the pre-clinical phase of AD (i.e., mild cognitive impairment) as well as in cognitively healthy persons at high-risk for developing AD due to family history or genetic factors. Studies have used a variety of imaging modalities (e.g., SPECT, MRI, PET) to investigate AD, but with its recent technological advancements and non-invasive use of blood water as an endogenous tracer, arterial spin labeling (ASL) MRI has become an imaging technique of growing popularity. Through numerous ASL studies, it is now known that AD is associated with both global and regional cerebral hypoperfusion and that there is considerable overlap between the regions implicated in the disease state (consistently reported in precuneus/posterior cingulate and lateral parietal cortex) and those implicated in disease risk. Debate exists as to whether decreased blood flow in AD is a cause or consequence of the disease. Nonetheless, hypoperfusion in AD is associated with both structural and functional changes in the brain and offers a promising putative biomarker that could potentially identify AD in its pre-clinical state and be used to explore treatments to prevent, or at least slow, the progression of the disease. Finally, given that perfusion is a vascular phenomenon, we provide insights from a vascular lesion model (i.e., stroke) and illustrate the influence of disrupted perfusion on brain structure and function and, ultimately, cognition in AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据