期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 27, 期 3, 页码 477-482出版社
IOS PRESS
DOI: 10.3233/JAD-2011-110650
关键词
Alzheimer's disease; cognitive disorder; cognitive flexibility; dopamine; excitotoxicity; GABA(A); hippocampus; learning and memory; memantine; mental flexibility; mice; mouse; muscarinic cholinergic system; neurotoxicity; NMDAR; platform re-location water maze; prefrontal cortex
资金
- Canadian Institute of Health Research (CIHR)
- Nickel-a-Drink Foundation
- Bank of Montreal
- James F. Crothers Foundation
- Margaret and Howard Gamble Foundation
Alzheimer's disease (AD) is multi-factorial mental disorder characterized by a copious array of congruent features cumulating in disrupted memory and dysthymia. Though the mechanism remains elusive, the highly unspecific pharmaceutical, memantine, provides modest benefits for patients with moderate-to-severe AD. A greater understanding of how memantine affects cognitive function promises to facilitate the search for better therapeutics. We therefore examined cognitive flexibility of mice following 5 and 10 mg/kg memantine administration using a platform re-location water maze. Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据