期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 21, 期 4, 页码 1153-1164出版社
IOS PRESS
DOI: 10.3233/JAD-2010-100702
关键词
Alzheimer's disease; amyloid-beta peptide; biomarker; cardiac surgery; cerebrospinal fluid; cognitive function; postoperative cognitive decline; S100 beta; tau
资金
- Asklepios-Med (Hungary)
- Hungarian Scientific Research Fund, Hungary [OTKA 043418]
- National Office for Research and Technology, Hungary [NKTH 8/2004]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Russian Federal Agency for Science and Innovations government, Russia [FCP 02.740.11.0302]
- Russian Foundation for Basic Research, Russia [RFBR 10-04-00883]
- NATO reintegration [NR.RIG.983007]
- Centre of Excellence grant (The Physiological Society, UK)
- Alzheimer's Association, USA [NIRG-08-87887]
Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-beta peptide, tau, and S100 beta in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100 beta was observed one week after the surgery, a mark of a severe generalized cerebral injury. The level of amyloid-beta peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据