期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 21, 期 1, 页码 221-228出版社
IOS PRESS
DOI: 10.3233/JAD-2010-091012
关键词
Brain reserve; cognitive reserve; education; mild cognitive impairment; neurochemical biomarkers
资金
- Alzheimer-fonden
- Sahlgrenska University Hospital
- Adlerbert Research Foundation
- Wilhelm and Martina Lundgren Foundation
- Hjalmar Svensson Foundation
- Swedish Medical Research Council [09946]
The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e. g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau (t-tau) and amyloid-beta(42), and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.
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