期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 16, 期 4, 页码 809-821出版社
IOS PRESS
DOI: 10.3233/JAD-2009-0976
关键词
Alzheimer's disease; inflammation; insulin; insulin-degrading enzyme; nuclear factor-kappa B; receptor for advanced glycation endproducts (RAGE); tumor necrosis factor; type 2 diabetes mellitus
Inflammatory processes are a hallmark of many chronic diseases including Alzheimer's disease and diabetes mellitus. Fairly recent statistical evidence indicating that type 2 diabetes increases the risk of developing Alzheimer's disease has led to investigations of the potential common processes that could explain this relation. Here, we review the literature on how inflammation and the inducible nuclear factor NF-kappa B might be involved in both diabetes mellitus and Alzheimer's disease and whether these factors can link both diseases.
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