期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 16, 期 4, 页码 787-808出版社
IOS PRESS
DOI: 10.3233/JAD-2009-0973
关键词
Alzheimer's disease; energy homeostasis; insulin signaling; metabolic syndrome; transcription; type 2 diabetes
资金
- Deutsche Forschungsgemeinschaft
- Thyssen Foundation
- Network Aging Research Heidelberg/Mannheim
- European Foundation for the Study of Diabetes
- Novartis Foundation for Therapeutic Research
- Marie Curie Excellence Grant (European Union)
Numerous epidemiological and experimental studies have established a strong connection between type 2 diabetes and the risk of the development of Alzheimer's disease. Indeed, several pathological features have been identified as common denominators of diabetic and Alzheimer's patients, including insulin resistance, dyslipidemia and inflammation, suggesting a close connection between the two disorders. Here we review common metabolic and inflammatory processes implicated in the pathogenesis of both disorders. In particular, the role of critical transcriptional checkpoints in the control of cellular metabolism, insulin sensitivity, and inflammation will be emphasized in this context. These transcriptional regulators hold great promise as new therapeutic targets in the potentially combined treatment of type 2 diabetes and Alzheimer's disease in the future.
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